The Definitive Guide to LDN-27219 preclinical research
One particular notably exciting compound is LDN-27219. Although most tTG inhibitors are created to bind towards the protein crosslinking Lively web site, LDN-27219 as an alternative binds towards the nucleotide binding pocket of your enzyme when it truly is in its shut-point out conformation, and stabilizes that conformation to avoid crosslinking a